Anti-LXR alpha + LXR beta antibody (ab216691)
Key features and details
- Rabbit polyclonal to LXR alpha + LXR beta
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-LXR alpha + LXR beta antibody
See all LXR alpha + LXR beta primary antibodies -
Description
Rabbit polyclonal to LXR alpha + LXR beta -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Synthetic peptide aa 400 to the C-terminus conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q13133 -
Positive control
- Huh7 and mouse liver lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab216691 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/100 - 1/1000.
|
Notes |
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WB
1/100 - 1/1000. |
Target
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Relevance
LXR alpha and LXR beta are orphan receptors. Interaction with RXR shifts RXR from its role as a silent DNA binding partner to an active ligand binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4 type response elements characterized by direct repeats of two similar hexanuclotide half sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis. LXR alpha: Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. LXR beta: Ubiquitously expressed. -
Cellular localization
Nuclear -
Database links
- Entrez Gene: 10062 Human
- Entrez Gene: 7376 Human
- Entrez Gene: 22259 Mouse
- Entrez Gene: 58852 Rat
- Omim: 602423 Human
- SwissProt: P55055 Human
- SwissProt: Q13133 Human
- SwissProt: Q91X41 Mouse
see all -
Alternative names
- Liver X receptor alpha antibody
- Liver X receptor beta antibody
- LXR a antibody
see all
Images
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Anti-LXR alpha + LXR beta antibody (ab216691) at 1/300 dilution (overnight at 4°C) + Huh7 lysates
Secondary
Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution -
Anti-LXR alpha + LXR beta antibody (ab216691) at 1/300 dilution (overnight at 4°C) + Mouse liver lysate
Secondary
Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab216691 has been referenced in 1 publication.
- Aboumsallem JP et al. Successful treatment of established heart failure in mice with recombinant HDL (Milano). Br J Pharmacol 175:4167-4182 (2018). PubMed: 30079544