Overview

  • Product name
  • Description
    Rabbit polyclonal to LXR alpha
  • Host species
    Rabbit
  • Specificity
    At leastthree isoforms of LXR alpha are known to exist; ab106464 will recognize all three. ab106464 is predicted to not crossreact with LXR beta.
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 15 amino acids from near the N terminal end of Human LXR alpha (NP_005684).

  • Positive control
    • Rat liver tissue and tissue lysate.

Applications

Our Abpromise guarantee covers the use of ab106464 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
  • Tissue specificity
    Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Liver X receptor alpha antibody
    • LXR a antibody
    • LXRA antibody
    • NR1H3 antibody
    • NR1H3_HUMAN antibody
    • Nuclear receptor subfamily 1 group H member 3 antibody
    • Oxysterols receptor LXR alpha antibody
    • Oxysterols receptor LXR-alpha antibody
    • RLD 1 antibody
    • RLD1 antibody
    see all

Images

  • Immunofluorescence of LXR alpha in rat liver tissue with ab106464 at 20 ug/mL.

  • Immunohistochemistry of rat liver tissue with ab106464 at 5 μg/mL

  • Lane 1 : Anti-LXR alpha antibody (ab106464) at 1 µg/ml
    Lane 2 : Anti-LXR alpha antibody (ab106464) at 2 µg/ml

    All lanes : Rat liver tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 50 kDa

References

This product has been referenced in:
  • Bakry OA  et al. Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-a in Acne Vulgaris. J Clin Diagn Res 11:WC01-WC07 (2017). Read more (PubMed: 29207817) »
  • Luo T  et al. Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells. J Immunol 197:3861-3870 (2016). Read more (PubMed: 27742830) »

See all 2 Publications for this product

Customer reviews and Q&As

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