Recombinant
RabMAb

Anti-LXR alpha antibody [EPR6508(N)] - BSA and Azide free (ab190727)

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Overview

  • Product name
    Anti-LXR alpha antibody [EPR6508(N)] - BSA and Azide free
    See all LXR alpha primary antibodies
  • Description
    Rabbit monoclonal [EPR6508(N)] to LXR alpha - BSA and Azide free
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WB, ICC/IFmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Sheep, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human LXR alpha aa 50-150 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q13133

  • Positive control
    • Human fetal liver, Jurkat and MCF-7 cell lysates. Jurkat cells and MCF7 cells.
  • General notes

    Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Applications

Our Abpromise guarantee covers the use of ab190727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab199376 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
WB Use at an assay dependent concentration. Predicted molecular weight: 50 kDa.

Can be blocked with LXR alpha peptide (ab191835).
ICC/IF Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for IHC-P or IP.

    • Target

    • Function
      Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
    • Tissue specificity
      Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
    • Sequence similarities
      Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
      see all
    • Alternative names
      • Liver X receptor alpha antibody
      • LXR a antibody
      • LXRA antibody
      • NR1H3 antibody
      • NR1H3_HUMAN antibody
      • Nuclear receptor subfamily 1 group H member 3 antibody
      • Oxysterols receptor LXR alpha antibody
      • Oxysterols receptor LXR-alpha antibody
      • RLD 1 antibody
      • RLD1 antibody
      see all

    References

    ab190727 has not yet been referenced specifically in any publications.

    Publishing research using ab190727? Please let us know so that we can cite the reference in this datasheet.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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