Negative control for LY 294002 (ab120243). PI3K inhibitory activity. Inhibits voltage-gated Kv channel activity (IC50 = 64.6 μM). Various pharmacological effects including inhibition of LPS-stimulated FPR1 expression and induction of H2O2 production.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM, in ethanol to 100 mM and in 1 eq. HCl to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Shenoy K et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res69:1941-50 (2009).
Read more (PubMed: 19223550) »
Mandal P & Hamilton T Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages. J Immunol178:2542-8 (2007).
Read more (PubMed: 17277163) »
Poh TW & Pervaiz S LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res65:6264-74 (2005).
Read more (PubMed: 16024628) »
El-Kholy W et al. The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J17:720-2 (2003).
Read more (PubMed: 12586735) »