Overview

  • Product name
    LY 303511 dihydrochloride
  • Description
    Negative control for LY 294002 (ab120243)
  • Biological description
    Negative control for LY 294002 (ab120243). PI3K inhibitory activity. Inhibits voltage-gated Kv channel activity (IC50 = 64.6 μM). Various pharmacological effects including inhibition of LPS-stimulated FPR1 expression and induction of H2O2 production.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Shenoy K  et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res 69:1941-50 (2009). Read more (PubMed: 19223550) »
  • Mandal P & Hamilton T Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages. J Immunol 178:2542-8 (2007). Read more (PubMed: 17277163) »
  • Poh TW & Pervaiz S LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res 65:6264-74 (2005). Read more (PubMed: 16024628) »
  • El-Kholy W  et al. The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J 17:720-2 (2003). Read more (PubMed: 12586735) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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