Overview

  • Product name
    LY 310762 hydrochloride
  • Description
    Potent, 5-HT1D antagonist
  • Biological description
    Potent, 5-HT1D receptor preferring antagonist (Ki values are ~100 and 32 nM at 5-HT1D and 5-HT1B receptors, respectively). Potentiates extracellular 5-HT concentrations (EC50 = 31 nM as measured by increase in [3H]5-HT outflow from cortical slices).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Pullar IA  et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol 493:85-93 (2004). Read more (PubMed: 15189767) »
  • Filip M & Bader M Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system. Pharmacol Rep 61:761-77 (0). Read more (PubMed: 19903999) »

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