Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199).
Water-soluble and very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Disodium salt of LY 341495 (ab120199) which displays Kd values of 1.67 (human mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 (human mGlu8a receptors) nM. LY 341495 displays IC50 values of 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. It is readily brain penetrant and active in vivo.
Also available in simple stock solutions (ab144500) - add 1 ml of water to get an exact, ready-to-use concentration.
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid disodium salt
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.