Biological descriptionHighly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.
Chemical name(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 eq. NaOH to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Linden AM et al. Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl)179:284-91 (2005).
Read more (PubMed: 15619115) »
Klodzinska A et al. Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology38:1831-9 (1999).
Read more (PubMed: 10608278) »
Schoepp DD et al. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology36:1-11 (1997).
Read more (PubMed: 9144636) »