Overview

  • Product nameLY 379268
  • Description
    Group II mGlu agonist. Systemically active.
  • Biological descriptionHighly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
  • Purity> 99%

Properties

    References for LY 379268 (ab120196)

    This product has been referenced in:
    • Imre G The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268. CNS Drug Rev 13:444-64 (2007). Read more (PubMed: 18078428) »
    • Collado I  et al. (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties. J Med Chem 45:3619-29 (2002). Read more (PubMed: 12166935) »
    • Moldrich RX  et al. Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology 41:8-18 (2001). Read more (PubMed: 11445181) »

    See all 6 Publications for this product

    Product Wall

    Je suis désolé mais je n'ai pas reçu de réponse du laboratoire concernant le problème de solubilisation du LY 379268.
    Désolé pour le délai de notre réponse et merci pour votre patience.

    Since the compound has not dissolved then it depends whether all of the DMSO needs to be removed as this will be extremely difficult.

    If DMSO is not a problem then it may be possible to dissolve the compound by adding water and warming gently...

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    My colleagues have carried out NMR and solubility testing with LY 379268 (ab120196). The NMR confirms that this compound is definitely LY 379268 and they have had no issue with solubility, even though the chemist reported that it took some time and pro...

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    Thank you for your message and your feedback.
    My colleagues from the lab agree with the suggestion of adding the 1eq of NaOH at the same time as the water if there is a similar issue with the new lot, as this should help.
    Also, my colleagues ar...

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    Thank you for confirming these details and for your cooperation.
    I forwarded your email to my colleagues, the details provided enable us to closely monitor the quality of our products.
    I am sorry this product did not perform as stated on the ...

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    Merci de nous avoir contactés et pour votre patience.
    Voici la réponse que j'ai reçu du laboratoire:
    "Our chemists have tested this batch and have the following advice:
    We would recommend that heat and sonication is used.
    · Heat in a 60...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"