Biological descriptionSelective non-competitive antagonist at the mGlu1 receptor. Inhibits agonist induced phosphoinositide hydrolysis in vitro (IC50 = 140 nM) and in vivo following systemic administration.
Chemical name(4-Methoxyphenyl)-(6-methoxy-quinazolin-4-yl)amine hydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Barton ME & Shannon HE Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice. Neuropharmacology48:779-87 (2005).
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Shannon HE et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology49 Suppl 1:188-95 (2005).
Read more (PubMed: 16011839) »