Overview

  • Product name
    LY 456236
  • Description
    mGlu1 non competitive antagonist
  • Biological description
    Selective non-competitive antagonist at the mGlu1 receptor. Inhibits agonist induced phosphoinositide hydrolysis in vitro (IC50 = 140 nM) and in vivo following systemic administration.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Barton ME & Shannon HE Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice. Neuropharmacology 48:779-87 (2005). Read more (PubMed: 15829250) »
  • Shannon HE  et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 49 Suppl 1:188-95 (2005). Read more (PubMed: 16011839) »

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