Overview

  • Product name
    Anti-Ly49C+F+H+I antibody [14B11] (Biotin)
    See all Ly49C+F+H+I primary antibodies
  • Description
    Syrian Hamster monoclonal [14B11] to Ly49C+F+H+I (Biotin)
  • Conjugation
    Biotin
  • Specificity
    ab93505 reacts with a subset of mouse Ly49 receptors and recognizes a majority of mouse NK cells. It reacts with 3 putative inhibitory members of the Ly49 family, F, I, and C and one putative activating receptor, Ly49H. It does not react with Ly49A, B, D, or G.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control
    • Mouse splenocytes
  • General notes


    ab93505 is reported to enhance the redirected lysis of FcR+ target cells by IL-2-activated NK cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, 150mM Sodium chloride, pH 7.2
  • Concentration information loading...
  • Primary antibody notes
    ab93505 is reported to enhance the redirected lysis of FcR+ target cells by IL-2-activated NK cells.
  • Clonality
    Monoclonal
  • Clone number
    14B11
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab93505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.25µg for 105 cells.

Use 0.25µg for 105 to 108 cells in a final volume of 100µl.





ab18486-Syrian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Relevance
    Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.
  • Cellular localization
    Plasma membrane
  • Database links
  • Alternative names
    • 5E6 antibody
    • Cmv-1 antibody
    • Cmv1 antibody
    • Killer cell lectin like receptor 3 antibody
    • Killer cell lectin like receptor 6 antibody
    • Killer cell lectin like receptor 8 antibody
    • Killer cell lectin like receptor 9 antibody
    • Killer cell lectin-like receptor subfamily A, member 9 antibody
    • Killer cell lectin-like receptor, subfamily A, member 3 antibody
    • Killer cell lectin-like receptor, subfamily A, member 6 antibody
    • Killer cell lectin-like receptor, subfamily A, member 8 antibody
    • Klra3 antibody
    • Klra3 protein antibody
    • Klra6 antibody
    • Klra8 antibody
    • Klra9 antibody
    • Ly49 C antigen antibody
    • Ly49 F antigen antibody
    • Ly49 H antigen antibody
    • Ly49 I antigen antibody
    • Ly49c antibody
    • Ly49f antibody
    • Ly49h antibody
    • Ly49I antibody
    • LY49I1 antibody
    • Ly49u<129> antibody
    • Lymphocyte antigen 49C antibody
    • Lymphocyte antigen 49F antibody
    • Lymphocyte antigen 49H antibody
    • Lymphocyte antigen 49I antibody
    • MGC123910 antibody
    • MHC class I recognition receptor Ly49I antibody
    • Natural killer cell receptor Ly49C antibody
    • Nk-2 antibody
    • NK-2.1 antibody
    • Nk2 antibody
    • Nk2.1 antibody
    • T cell surface glycoprotein Ly 49C antibody
    • T cell surface glycoprotein Ly 49F antibody
    • T cell surface glycoprotein Ly 49H antibody
    • T cell surface glycoprotein Ly 49I antibody
    see all

References

This product has been referenced in:
  • Corral L  et al. A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Hybridoma 18:359-66 (1999). Read more (PubMed: 10571266) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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