Overview

  • Product name
    Anti-LY75 antibody [NLDC-145] (Biotin)
    See all LY75 primary antibodies
  • Description
    Rat monoclonal [NLDC-145] to LY75 (Biotin)
  • Conjugation
    Biotin
  • Specificity
    Reacts with Mouse non lymphoid dendritic cells: interdigitating cells (IDC), veiled cells and Langerhans cells, thymic epithelial cells.
  • Tested applications
    Suitable for: Flow Cyt, IHC-Frmore details
    Unsuitable for: IHC-P
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse lymph node tissue

  • Epitope
    The antigen is a protein of 205kDa molecular weight which is localized on the cell surface and intracellularly. The epitope has not been further characterized.
  • Positive control
    • The following tissues also tested positive: Lymph node, Peyer’s patch, Thymus and Skin.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, 5mg/ml BSA, pH 7.2
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    NLDC-145
  • Isotype
    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab51820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IHC-Fr
  • Application notes
    Flow Cyt: Use at an assay dependent dilution (PMID 19109143).
    IHC-Fr: Use at a concentration of 3 µg/ml.


    Is unsuitable for IHC-P.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
    • Tissue specificity
      Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
    • Sequence similarities
      Contains 10 C-type lectin domains.
      Contains 1 fibronectin type-II domain.
      Contains 1 ricin B-type lectin domain.
    • Post-translational
      modifications
      N-glycosylated.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • C-type lectin domain family 13 member B antibody
      • CD 205 antibody
      • CD205 antibody
      • CD205 antigen antibody
      • CLEC 13B antibody
      • CLEC13B antibody
      • DEC 205 antibody
      • DEC-205 antibody
      • DEC205 antibody
      • gp200 antibody
      • gp200 MR6 antibody
      • gp200-MR6 antibody
      • LY 75 antibody
      • Ly-75 antibody
      • LY75 antibody
      • LY75_HUMAN antibody
      • Lymphocyte antigen 75 antibody
      • Renal Cell Carcinoma (gp200) antibody
      see all

    References

    This product has been referenced in:
    • Reeh KA  et al. Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development 141:2950-8 (2014). IHC-P ; Mouse . Read more (PubMed: 25053428) »
    • Jenkinson SR  et al. TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A 110:21107-12 (2013). Mouse . Read more (PubMed: 24324158) »

    See all 7 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab51820.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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