Overview

  • Product nameAnti-LY75 antibody [RC38]
    See all LY75 primary antibodies
  • Description
    Mouse monoclonal [RC38] to LY75
  • SpecificityRC38 stains over 95% of primary renal cell carcinomas and 60% of metastases of renal cell carcinoma and glomerular visceral epithelium and proximal tubules in normal kidney (cytoplasmic). It does not stain epithelial cells of non renal malignancies.
  • Tested applicationsSuitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A mouse was immunized with renal cell carcinoma homogenate. After fusing the spleen cells from this mouse with myeloma cells, antibody producing cells were screened on thin sections of various human tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab2489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
  • Application notesIHC-Fr: Use at an assay dependent concentration.
    Supernatant: for frozen tissue sections it can be diluted 1:20 in PBS/1%BSA.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
    • Tissue specificityExpressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
    • Sequence similaritiesContains 10 C-type lectin domains.
      Contains 1 fibronectin type-II domain.
      Contains 1 ricin B-type lectin domain.
    • Post-translational
      modifications
      N-glycosylated.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • C-type lectin domain family 13 member B antibody
      • CD 205 antibody
      • CD205 antibody
      • CD205 antigen antibody
      • CLEC 13B antibody
      • CLEC13B antibody
      • DEC 205 antibody
      • DEC-205 antibody
      • DEC205 antibody
      • gp200 antibody
      • gp200 MR6 antibody
      • gp200-MR6 antibody
      • LY 75 antibody
      • Ly-75 antibody
      • LY75 antibody
      • LY75_HUMAN antibody
      • Lymphocyte antigen 75 antibody
      • Renal Cell Carcinoma (gp200) antibody
      see all

    Anti-LY75 antibody [RC38] images

    • ab2489 staining human renal cell carcinoma by Immunohistochemistry (frozen sections).

    References for Anti-LY75 antibody [RC38] (ab2489)

    ab2489 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"