Overview

  • Product name
    Anti-Lymphotoxin Beta antibody
    See all Lymphotoxin Beta primary antibodies
  • Description
    Rabbit polyclonal to Lymphotoxin Beta
  • Specificity
    ab64835 detects endogenous levels of total Lymphotoxin Beta protein.
  • Tested applications
    Suitable for: IHC-P, ELISA, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide derived from C-terminal of human Lymphotoxin Beta

  • Positive control
    • HepG2 cell extracts and HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab64835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration. PubMed: 22354988
ELISA 1/10000.
ICC/IF 1/500 - 1/1000.
WB 1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).

Target

  • Function
    Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
  • Tissue specificity
    Spleen and thymus.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • LT beta antibody
    • LT-beta antibody
    • Ltb antibody
    • lymphotoxin beta antibody
    • Lymphotoxin-beta antibody
    • p33 antibody
    • TNF-C antibody
    • TNFC antibody
    • TNFC_HUMAN antibody
    • TNFSF3 antibody
    • Tumor necrosis factor C antibody
    • Tumor necrosis factor ligand superfamily member 3 antibody
    see all

Images

  • All lanes : Anti-Lymphotoxin Beta antibody (ab64835) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with immunising peptide


    Predicted band size : 25 kDa
    Observed band size : 25 kDa
  • ab64835 at 1/500 - 1/1000 dilution staining Lymphotoxin Beta in HeLa cells by Immunofluorescence, in the absence (-) or presence (+) of the immunising peptide.

References

This product has been referenced in:
  • Yim RL  et al. Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin's lymphomas. Oncotarget 5:9770-82 (2014). Flow Cyt . Read more (PubMed: 25211095) »
  • Simonin Y  et al. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog 9:e1003234 (2013). WB, IHC-P ; Mouse . Read more (PubMed: 23555249) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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