The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 - 12.5 µg/ml.
FunctionSupports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Tissue specificityExpressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.
Sequence similaritiesContains 2 UPAR/Ly6 domains.
Post-translational modificationsN-glycosylated and O-glycosylated.