Overview

  • Product nameAnti-LYRIC antibody
    See all LYRIC primary antibodies
  • Description
    Rabbit polyclonal to LYRIC
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Ferret, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 75-125 of Human LYRIC (NP_848927.2)

  • Positive control
    • HeLa cell lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionDownregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
    • Tissue specificityWidely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
    • Cellular localizationEndoplasmic reticulum membrane. Nucleus membrane. Cell junction > tight junction. Nucleus > nucleolus. Cytoplasm > perinuclear region. In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3D3 antibody
      • 3D3/LYRIC antibody
      • AEG 1 antibody
      • AEG-1 antibody
      • AEG1 antibody
      • Astrocyte elevated gene 1 antibody
      • Astrocyte elevated gene-1 protein antibody
      • LYRIC antibody
      • LYRIC/3D3 antibody
      • LYRIC_HUMAN antibody
      • Lysine rich CEACAM1 associated protein antibody
      • Lysine rich CEACAM1 co isolated protein antibody
      • Lysine-rich CEACAM1 co-isolated protein antibody
      • Metadherin antibody
      • Metastasis adhesion protein antibody
      • MTDH antibody
      • Protein LYRIC antibody
      see all

    Anti-LYRIC antibody images

    • Detection of LYRIC by Western Blot of Immunprecipitate.
      An antibody to LYRIC at 1µg/ml staining LYRIC in HeLa whole cell lysate immunoprecipitated using ab113204at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.

    References for Anti-LYRIC antibody (ab113204)

    ab113204 has not yet been referenced specifically in any publications.

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