Anti-Lysosomal acid lipase antibody (ab89771)

Overview

  • Product nameAnti-Lysosomal acid lipase antibody
    See all Lysosomal acid lipase primary antibodies
  • Description
    Mouse polyclonal to Lysosomal acid lipase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human Lysosomal acid lipase, amino acids 1-399 (AAH12287.1)

  • Positive control
    • Human pancreas tissue lysate, Lysosomal acid lipase transfected 293T cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab89771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.

Target

  • FunctionCrucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
  • Involvement in diseaseDefects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
    Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset.
  • Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acid cholesteryl ester hydrolase antibody
    • CESD antibody
    • cholesterol ester hydrolase antibody
    • cholesterol ester storage disease antibody
    • Cholesteryl esterase antibody
    • Hydrolase deficiency antibody
    • LAL antibody
    • LAL deficiency cholesterol ester antibody
    • LICH_HUMAN antibody
    • lipA antibody
    • LIPA deficiency antibody
    • Lipase A antibody
    • lipase A, lysosomal acid, cholesterol esterase antibody
    • lysosomal acid lipase antibody
    • lysosomal acid lipase deficiency antibody
    • Lysosomal acid lipase/cholesteryl ester hydrolase antibody
    • Sterol esterase antibody
    see all

Anti-Lysosomal acid lipase antibody images

  • Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg

    Predicted band size : 45 kDa
    Observed band size : 45 kDa
  • All lanes : Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml

    Lane 1 : Lysosomal acid lipase transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 45 kDa
    Observed band size : 45 kDa

References for Anti-Lysosomal acid lipase antibody (ab89771)

ab89771 has not yet been referenced specifically in any publications.

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