Overview

  • Product name
  • Description
    Mouse monoclonal to LYST
  • Tested applications
    Suitable for: ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).

Properties

Applications

Our Abpromise guarantee covers the use of ab118121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

Target

  • Function
    May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
  • Tissue specificity
    Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
  • Involvement in disease
    Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
  • Sequence similarities
    Contains 1 BEACH domain.
    Contains 7 WD repeats.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beige homolog antibody
    • beige protein antibody
    • Chediak-Higashi syndrome 1 antibody
    • CHS antibody
    • CHS1 antibody
    • Lysosomal-trafficking regulator antibody
    • LYST antibody
    • LYST_HUMAN antibody
    • OTTHUMP00000038327 antibody
    see all

Images

  • Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.

References

ab118121 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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