Overview

  • Product nameAnti-LYST antibody
  • Description
    Mouse monoclonal to LYST
  • Tested applicationsSuitable for: ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).

Properties

Applications

Our Abpromise guarantee covers the use of ab118121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

Target

  • FunctionMay be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
  • Tissue specificityAbundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
  • Involvement in diseaseDefects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
  • Sequence similaritiesContains 1 BEACH domain.
    Contains 7 WD repeats.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beige homolog antibody
    • beige protein antibody
    • Chediak-Higashi syndrome 1 antibody
    • CHS antibody
    • CHS1 antibody
    • Lysosomal-trafficking regulator antibody
    • LYST antibody
    • LYST_HUMAN antibody
    • OTTHUMP00000038327 antibody
    see all

Anti-LYST antibody images

  • Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.

References for Anti-LYST antibody (ab118121)

ab118121 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118121.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"