FormLyophilised:The biotinylated antibody should be reconstituted to a concentration of 50 µg/ml with sterile PBS solution containing 0.1% BSA. This solution can be stored at 4°C for at least one month without detectable loss of activity. Frozen aliquots of this solution are stable for at least 6 months when kept at -20°C.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 3 - 10 µg/ml. ab200208-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
FunctionLigand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Tissue specificityMainly expressed in endothelial cells lining lymphatic vessels.
Sequence similaritiesContains 1 Link domain.
Cellular localizationMembrane. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.