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Overview
Product name
Anti-mSin3A antibody
See all mSin3A products (4) ...
Description
Rabbit polyclonal to mSin3A
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to a region within residues 1 - 50 of Human mSin3A (NP_056292.1)
Positive control
Human ovarian tumor; Mouse squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab84380 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 2 Images
IHC-P
Application notes
IHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Mammalian Sin 3 (mSin 3) is a protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin 3A and mSin 3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin 3A and mSin 3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC 1, HDAC 2, RbAp 46, the methyl CpG binding protein MeCP 2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid & thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR).
Cellular localization
Nuclear. Nucleolus. Note=Recruited to the nucleolus by SAP30L.
Alternative names
- DKFZP434K2235 antibody
- FLJ90319 antibody
- Histone deacetylase complex subunit Sin 3a antibody
see all
Database links
- Entrez Gene: 25942 Human
- Entrez Gene: 20466 Mouse
- Omim: 607776 Human
- SwissProt: Q96ST3 Human
- SwissProt: Q60520 Mouse
Anti-mSin3A antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - mSin3A antibody (ab84380)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84380. Detection: DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - mSin3A antibody (ab84380)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian tumor tissue using 1/250 ab84380. Detection: DAB staining.
References for Anti-mSin3A antibody (ab84380)
ab84380 has not yet been referenced specifically in any publications.
Publishing research using ab84380? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"