The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 97 kDa.
1/10000 - 1/40000.
Use a concentration of 2.5 µg/ml.
FunctionActs as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Tissue specificityPreferentially expressed in metastasizing tumors.
Sequence similaritiesContains 1 SH3 domain.
Cellular localizationCytoplasm. Nucleus. Mainly found in the cytoplasm in non-metastasizing tumors.