Anti-MACROD1 antibody - N-terminal (ab157603)

Overview

  • Product name
    Anti-MACROD1 antibody - N-terminal
    See all MACROD1 primary antibodies
  • Description
    Rabbit polyclonal to MACROD1 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 83-132 of Human MACROD1 (NP_054786).

  • Positive control
    • Human fetal brain lysate

Applications

Our Abpromise guarantee covers the use of ab157603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa.

Target

  • Function
    Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
  • Involvement in disease
    Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
  • Sequence similarities
    Contains 1 Macro domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • LRP16 antibody
    • MACD1_HUMAN antibody
    • MACRO domain containing 1 antibody
    • MACRO domain-containing protein 1 antibody
    • Macrod1 antibody
    • O-acetyl-ADP-ribose deacetylase MACROD1 antibody
    • Protein LRP16 antibody
    see all

Images

  • Anti-MACROD1 antibody - N-terminal (ab157603) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size: 36 kDa

References

ab157603 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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