Anti-CCL4/MIP-1 beta antibody (ab106548)
Key features and details
- Rabbit polyclonal to CCL4/MIP-1 beta
- Suitable for: WB
- Reacts with: Pig
- Isotype: IgG
Overview
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Product name
Anti-CCL4/MIP-1 beta antibody
See all CCL4/MIP-1 beta primary antibodies -
Description
Rabbit polyclonal to CCL4/MIP-1 beta -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Pig
Predicted to work with: Rat, Rabbit, Horse, Cow, Cat, Dog, Chimpanzee, Macaque monkey, Opossum -
Immunogen
Recombinant full length protein corresponding to Pig CCL4/MIP-1 beta aa 1 to the C-terminus. Mature full length chain without signal peptide.
Database link: Q711P4 -
Positive control
- Recombinant Pig CCL4/MIP-1 beta.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
ab106548 was Protein A purified from monospecific antiserum by chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106548 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500. Predicted molecular weight: 10 kDa.
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Notes |
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WB
1/500. Predicted molecular weight: 10 kDa. |
Target
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Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 414347 Cow
- Entrez Gene: 448786 Dog
- Entrez Gene: 100057859 Horse
- Entrez Gene: 116637 Rat
- SwissProt: Q17QA1 Cow
- SwissProt: Q68AZ0 Dog
- SwissProt: P50230 Rat
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Alternative names
- MIP 1 beta antibody
- Secreted protein G 26 antibody
- ACT 2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab106548 has not yet been referenced specifically in any publications.