ab106151 was prepared from whole Rabbit serum produced by repeated immunizations with recombinant full length Mouse MIP-3a protein.
Recombinant Mouse Ccl20 protein
FormLyophilised:Centrifuge product if not completely clear after standing at room temperature. Restore with 0.1 mL of deionized water (or equivalent). Dilute only prior to immediate use. Expiration date is one (1) year from date of restoration.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 11 kDa.
FunctionChemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.
Tissue specificityExpressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsC-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.