Anti-Macrophage Scavenger Receptor I antibody (ab123946)

Overview

  • Product name
    Anti-Macrophage Scavenger Receptor I antibody
    See all Macrophage Scavenger Receptor I primary antibodies
  • Description
    Rabbit polyclonal to Macrophage Scavenger Receptor I
  • Tested applications
    Suitable for: WB, ICC/IF, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Cow, Cat, Human, Monkey
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 300-400 of Human Macrophage Scavenger Receptor I (UniProt P21757).

  • Positive control
    • Hela cells; Human liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab123946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).
ICC/IF 1/50 - 1/200.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function
    Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.
  • Tissue specificity
    Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
  • Sequence similarities
    Contains 1 collagen-like domain.
    Contains 1 SRCR domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD204 antibody
    • CD204 antigen antibody
    • CD24 antibody
    • Macrophage acetylated LDL receptor I and II antibody
    • Macrophage scavenger receptor 1 antibody
    • Macrophage scavenger receptor type III antibody
    • Macrophage scavenger receptor types I and II antibody
    • Msr 1 antibody
    • MSR1 antibody
    • MSRE_HUMAN antibody
    • phSR1 antibody
    • phSR2 antibody
    • SCARA 1 antibody
    • SCARA1 antibody
    • Scavenger receptor class A member 1 antibody
    • Scavenger receptor class A, member 1 antibody
    • Scavenger receptor type A antibody
    • Scvr antibody
    • SR A antibody
    • SRA antibody
    see all

Images

  • Anti-Macrophage Scavenger Receptor I antibody (ab123946) at 0.5 µg/ml + Human liver lysate

    Predicted band size : 50 kDa
    Observed band size : 50 kDa
  • ab123946, at a 1/50 dilution, staining Macrophage Scavenger Receptor I (green) in Hela cells by Immunofluorescence. Nuclei (blue) are counterstained using Hoechst 33258.

References

This product has been referenced in:
  • Pasterk L  et al. Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression. Sci Rep 6:22104 (2016). Read more (PubMed: 26905525) »
  • Tran HB  et al. Oxidative stress decreases functional airway mannose binding lectin in COPD. PLoS One 9:e98571 (2014). ICC/IF . Read more (PubMed: 24901869) »

See all 2 Publications for this product

Customer reviews and Q&As

Filter by Application

Filter by Species

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Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Rhesus monkey Tissue sections (Spleen)
Antigen retrieval step
Enzymatic
Permeabilization
No
Specification
Spleen
Blocking step
2.5% Normal Horse Serum - VectorLabs ImmPRESS™ Excel Amplified HRP Polymer Staining Kit (Anti-Mouse Ig) as blocking agent for 20 minute(s) · Concentration: 2.5% · Temperature: RT°C
Fixative
10% Neutral Buffered Formalin
Username

Dr. Basel Assaf

Verified customer

Submitted Jun 03 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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