FunctionAntagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Tissue specificityUbiquitous with higher expression in the lung and vascular endothelium.
Involvement in diseaseColorectal cancer 3
Sequence similaritiesBelongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain.
Post-translational modificationsPhosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1. Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation. Acetylation prevents ubiquitination and degradation mediated by SMURF1.
Cellular localizationNucleus. Cytoplasm. Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).
MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody
Mad homolog 7 antibody
MAD homolog 8 antibody
MAD mothers against decapentaplegic homolog 7 antibody
MADH 7 antibody
MADH 8 antibody
Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody
Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody
Mothers against decapentaplegic homolog 7 antibody
Mothers against decapentaplegic homolog 8 antibody
Mothers against DPP homolog 7 antibody
Mothers against DPP homolog 8 antibody
SMA- AND MAD-RELATED PROTEIN 7 antibody
SMAD 7 antibody
SMAD family member 7 antibody
SMAD, mothers against DPP homolog 7 (Drosophila) antibody
SMAD, mothers against DPP homolog 7 antibody
Anti-MADH7 antibody images
Western blot - MADH7 antibody (ab90086)
Anti-MADH7 antibody (ab90086) at 1/500 dilution + HeLa cell lysate
Predicted band size : 46 kDa
References for Anti-MADH7 antibody (ab90086)
This product has been referenced in:
Zhang Z et al. The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development. J Biol Chem288:37082-93 (2013).
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