Overview

  • Product nameAnti-MAGE 1 antibody
    See all MAGE 1 primary antibodies
  • Description
    Rabbit polyclonal to MAGE 1
  • SpecificityThis antibody is specific for MAGE 1 (N term).
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide (10-30 aa in length) in the region of aa 200~250 of human MAGE 1.

  • Positive control
    • Breast carcinoma tissue and Jurkat cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab38486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 25 kDa (predicted molecular weight: 24 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionMay be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • Tissue specificityExpressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
  • Sequence similaritiesContains 1 MAGE domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen MZ2 E antibody
    • Antigen MZ2-E antibody
    • Cancer/testis antigen 1.1 antibody
    • cancer/testis antigen family 1, member 1 antibody
    • CT1.1 antibody
    • MAGA1_HUMAN antibody
    • MAGE 1 antigen antibody
    • MAGE-1 antigen antibody
    • MAGE1 antibody
    • MAGE1A antibody
    • MAGEA1 antibody
    • Melanoma antigen 1 antibody
    • Melanoma antigen family A 1 (directs expression of antigen MZ2 E) antibody
    • Melanoma antigen family A 1 antibody
    • Melanoma antigen MAGE 1 antibody
    • Melanoma associated antigen 1 antibody
    • Melanoma associated antigen MZ2 E antibody
    • Melanoma-associated antigen 1 antibody
    • MGC9326 antibody
    see all

Anti-MAGE 1 antibody images

  • Anti-MAGE 1 antibody (ab38486) at 1/100 dilution + Jurkat cell lysate

    Predicted band size : 24 kDa
    Observed band size : 25 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 20 kDa,50 kDa,60 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with ab38486 at a 1/50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

References for Anti-MAGE 1 antibody (ab38486)

ab38486 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab38486.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"