Recombinant
RabMAb

Anti-MAGE 1 antibody [EPR4276] (ab109108)

Overview

  • Product name
    Anti-MAGE 1 antibody [EPR4276]
    See all MAGE 1 primary antibodies
  • Description
    Rabbit monoclonal [EPR4276] to MAGE 1
  • Tested applications
    Suitable for: WB, ICC, Flow Cytmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human MAGE 1.

  • Positive control
    • A375, HeLa, Jurkat, HepG2, and MCF7 lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab109108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 46 kDa (predicted molecular weight: 34 kDa).
ICC 1/100 - 1/250.
Flow Cyt 1/10 - 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function
      May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
    • Tissue specificity
      Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
    • Sequence similarities
      Contains 1 MAGE domain.
    • Cellular localization
      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Antigen MZ2 E antibody
      • Antigen MZ2-E antibody
      • Cancer/testis antigen 1.1 antibody
      • cancer/testis antigen family 1, member 1 antibody
      • CT1.1 antibody
      • MAGA1_HUMAN antibody
      • MAGE 1 antigen antibody
      • MAGE-1 antigen antibody
      • MAGE1 antibody
      • MAGE1A antibody
      • MAGEA1 antibody
      • Melanoma antigen 1 antibody
      • Melanoma antigen family A 1 (directs expression of antigen MZ2 E) antibody
      • Melanoma antigen family A 1 antibody
      • Melanoma antigen MAGE 1 antibody
      • Melanoma associated antigen 1 antibody
      • Melanoma associated antigen MZ2 E antibody
      • Melanoma-associated antigen 1 antibody
      • MGC9326 antibody
      see all

    Images

    • All lanes : Anti-MAGE 1 antibody [EPR4276] (ab109108) at 1/1000 dilution

      Lane 1 : A375 cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : Jurkat cell lysate
      Lane 4 : HepG2 cell lysate
      Lane 5 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 34 kDa
      Observed band size : 46 kDa (why is the actual band size different from the predicted?)

    References

    ab109108 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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