Recombinant
RabMAb

Anti-MAGE 1 antibody [SP194] - C-terminal (ab183309)

Overview

  • Product name
    Anti-MAGE 1 antibody [SP194] - C-terminal
    See all MAGE 1 primary antibodies
  • Description
    Rabbit monoclonal [SP194] to MAGE 1 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MAGE 1 (C terminal). The exact sequence is proprietary.
    Database link: P43355

  • Positive control
    • Human HeLa and A431 cell lysates. Human A431 cells. Human testis and skin squamous cell carcinoma tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab183309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/400. Predicted molecular weight: 34 kDa.
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt 1/400.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

Target

  • Function
    May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • Tissue specificity
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
  • Sequence similarities
    Contains 1 MAGE domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen MZ2 E antibody
    • Antigen MZ2-E antibody
    • Cancer/testis antigen 1.1 antibody
    • cancer/testis antigen family 1, member 1 antibody
    • CT1.1 antibody
    • MAGA1_HUMAN antibody
    • MAGE 1 antigen antibody
    • MAGE-1 antigen antibody
    • MAGE1 antibody
    • MAGE1A antibody
    • MAGEA1 antibody
    • Melanoma antigen 1 antibody
    • Melanoma antigen family A 1 (directs expression of antigen MZ2 E) antibody
    • Melanoma antigen family A 1 antibody
    • Melanoma antigen MAGE 1 antibody
    • Melanoma associated antigen 1 antibody
    • Melanoma associated antigen MZ2 E antibody
    • Melanoma-associated antigen 1 antibody
    • MGC9326 antibody
    see all

Images

  • Immunohistochemical analysis of Human testis tissue labeling MAGE 1 using ab183309 at a 1/100 dilution.

  • Immunohistochemical analysis of Human skin squamous cell carcinoma tissue labeling MAGE 1 using ab183309 at a 1/100 dilution.

  • Flow cytometric analysis of Human A431 cells labeling MAGE 1 using ab183309(1/400) (green) compared to a negative control rabbit IgG (blue)

  • Anti-MAGE 1 antibody [SP194] - C-terminal (ab183309) at 1/400 dilution + Human A431 cell lysate

    Predicted band size: 34 kDa

References

ab183309 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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