Overview

  • Product name
  • Description
    Rabbit polyclonal to MAGED1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Mouse MAGED1 aa 683-699 conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    C-EAEARAEARNRMGIGDE

  • Positive control
    • PC12 cell extracts

Properties

Applications

Our Abpromise guarantee covers the use of ab104627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 86 kDa.

Target

  • Function
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • Tissue specificity
    Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
  • Sequence similarities
    Contains 1 MAGE domain.
  • Cellular localization
    Cytoplasm. Cell membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
  • Information by UniProt
  • Database links
  • Alternative names
    • DLXIN 1 antibody
    • MAGD1_HUMAN antibody
    • MAGE D1 antigen antibody
    • MAGE tumor antigen CCF antibody
    • MAGE-D1 antigen antibody
    • Maged1 antibody
    • Melanoma antigen family D 1 antibody
    • Melanoma associated antigen D1 antibody
    • Melanoma-associated antigen D1 antibody
    • Neurotrophin receptor interacting MAGE homolog antibody
    • Neurotrophin receptor-interacting MAGE homolog antibody
    • NRAGE antibody
    • PP2250 antibody
    see all

Images

  • All lanes : Anti-MAGED1 antibody (ab104627) at 1/500 dilution

    Lane 1 : PC12 cell extracts with MAGED1 blocking peptide
    Lane 2 : PC12 cell extracts


    Predicted band size : 86 kDa

References

ab104627 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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