Overview

  • Product nameAnti-MAGED1 antibody
    See all MAGED1 primary antibodies
  • Description
    Mouse monoclonal to MAGED1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: EMADIQVSAA AARPKSAFKV QNATTKGPNG VYDFSQAHNA KDVPNTQPKA AFKSQNATPK GPNAAYDFSQ AATTGELAAN KSEMAFKAQN ATTKVGPNAT YNFSQSLNAN , corresponding to amino acids 117-227 of Human MAGED1 (NP_001005333) with a 26kDa enzyme tag

  • Positive control
    • Jurkat cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab77045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 86 kDa (predicted molecular weight: 86 kDa).

Target

  • FunctionInvolved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • Tissue specificityExpressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
  • Sequence similaritiesContains 1 MAGE domain.
  • Cellular localizationCytoplasm. Cell membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
  • Information by UniProt
  • Database links
  • Alternative names
    • DLXIN 1 antibody
    • MAGD1_HUMAN antibody
    • MAGE D1 antigen antibody
    • MAGE tumor antigen CCF antibody
    • MAGE-D1 antigen antibody
    • Maged1 antibody
    • Melanoma antigen family D 1 antibody
    • Melanoma associated antigen D1 antibody
    • Melanoma-associated antigen D1 antibody
    • Neurotrophin receptor interacting MAGE homolog antibody
    • Neurotrophin receptor-interacting MAGE homolog antibody
    • NRAGE antibody
    • PP2250 antibody
    see all

Anti-MAGED1 antibody images

  • Anti-MAGED1 antibody (ab77045) at 1/500 dilution + Jurkat cell lysate at 25 µg

    Secondary
    HRP-conjugated goat anti-mouse IgG at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 86 kDa
    Observed band size : 86 kDa
  • Anti-MAGED1 antibody (ab77045) at 1/500 dilution + immunogen (38.21 kDa) at 0.1 µg

    Secondary
    HRP-conjugated goat anti-mouse IgG at 1/5000 dilution
    Developed using the ECL technique

    Predicted band size : 86 kDa

References for Anti-MAGED1 antibody (ab77045)

ab77045 has not yet been referenced specifically in any publications.

Product Wall

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