Anti-MAGI3 antibody (ab111692)
Key features and details
- Rabbit polyclonal to MAGI3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MAGI3 antibody
See all MAGI3 primary antibodies -
Description
Rabbit polyclonal to MAGI3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 112-342 of Human MAGI3, isoform 1~4 (AAI30410).
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Positive control
- IMR32 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab111692 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 123 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 123 kDa. |
Target
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Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 6 PDZ (DHR) domains.
Contains 2 WW domains. -
Post-translational
modificationsUbiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. -
Cellular localization
Cell membrane. Cell junction > tight junction. Nucleus. Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions. - Information by UniProt
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Database links
- Entrez Gene: 260425 Human
- Entrez Gene: 99470 Mouse
- Entrez Gene: 245903 Rat
- SwissProt: Q5TCQ9 Human
- SwissProt: Q9EQJ9 Mouse
- SwissProt: Q9JK71 Rat
- Unigene: 486189 Human
- Unigene: 264849 Mouse
see all -
Alternative names
- dJ730K3.2 antibody
- MAGI-3 antibody
- magi3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab111692 has not yet been referenced specifically in any publications.