• Product name
  • Description
    Rabbit polyclonal to MAGI3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 716-979 of Human MAGI3 (BC130409).

  • Positive control
    • Human fetal brain, fetal kidney and fetal liver lysates; Human fetal testis tissue.


  • Form
    Lyophilised:Reconstitute in 200 µl sterile distilled water.
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab118615 is purified by protein affinity column.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab118615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 130, 160 kDa (predicted molecular weight: 123, 160 kDa).
IHC-P 1/100 - 1/500.


  • Function
    Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 6 PDZ (DHR) domains.
    Contains 2 WW domains.
  • Post-translational
    Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
  • Cellular localization
    Cell membrane. Cell junction > tight junction. Nucleus. Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ730K3.2 antibody
    • MAGI-3 antibody
    • magi3 antibody
    • MAGI3_HUMAN antibody
    • Membrane Associated Guanylate kinase Related 3 antibody
    • Membrane associated guanylate kinase, WW and PDZ domain containing 3 antibody
    • Membrane associated guanylate kinase, WW and PDZ domain containing protein 3 antibody
    • Membrane-associated guanylate kinase antibody
    • Membrane-associated guanylate kinase inverted 3 antibody
    • RP4-730K3.1 antibody
    • SLIPR antibody
    • WW and PDZ domain-containing protein 3 antibody
    see all


  • All lanes : Anti-MAGI3 antibody (ab118615) at 1/500 dilution

    Lane 1 : Human fetal brain lysate
    Lane 2 : Human fetal kidney lysate
    Lane 3 : Human fetal liver lysate

    Predicted band size : 123, 160 kDa
    Observed band size : 130,160 kDa (why is the actual band size different from the predicted?)
  • ab118615 at 1/100 dilution, staining MAGI3 in formalin fixed, paraffin embedded Human fetal testis tissue by Immunohistochemistry. Note membrane and nuclear staining.


ab118615 has not yet been referenced specifically in any publications.

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