Overview

  • Product nameAnti-MAGOH antibody
    See all MAGOH primary antibodies
  • Description
    Rabbit polyclonal to MAGOH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 45-74 of Human MAGOH (NP_002361.1).

  • Positive control
    • K-562 cell line lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab123399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 17 kDa.

Target

  • FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the mago nashi family.
  • Cellular localizationNucleus. Nucleus speckle. Cytoplasm. Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
  • Information by UniProt
  • Database links
  • Alternative names
    • Mago nashi homolog proliferation associated (Drosophila) antibody
    • Mago nashi protein homolog antibody
    • magoh antibody
    • MAGOHA antibody
    • MGN_HUMAN antibody
    • Protein mago nashi homolog antibody
    see all

Anti-MAGOH antibody images

  • Anti-MAGOH antibody (ab123399) at 1/100 dilution + K-562 cell line lysates at 35 µg

    Predicted band size : 17 kDa

References for Anti-MAGOH antibody (ab123399)

ab123399 has not yet been referenced specifically in any publications.

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