Overview

  • Product nameAnti-MAK antibody
    See all MAK primary antibodies
  • Description
    Mouse monoclonal to MAK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PPKQQSQEKP PQTLFPSIVK NMPTKPNGTL SHKSGRRRWG QTIFKSGDSW EELEDYDFGA SHSKKPSMGV FKEKRKKDSP FRQQVKMAVI SLSAHQFPTL , corresponding to amino acids 358-457 of Human MAK

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab55453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEssential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
    • Tissue specificityExpressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
    • Involvement in diseaseDefects in MAK are the cause of retinitis pigmentosa type 62 (RP62) [MIM:614181]. RP62 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
      Contains 1 protein kinase domain.
    • Post-translational
      modifications
      Autophosphorylated. Phosphorylated on serine and threonine residues.
    • Cellular localizationNucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Midbody. Cell projection > cilium > photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
    • Information by UniProt
    • Database links
    • Alternative names
      • intestinal cell kinase antibody
      • dJ417M14.2 antibody
      • fj04c02 antibody
      • Ick antibody
      • Mak antibody
      • MAK_HUMAN antibody
      • Male germ cell associated kinase antibody
      • Male germ cell-associated kinase antibody
      • male germ cell-associated kinase retinal-enriched isoform antibody
      • OTTHUMP00000016025 antibody
      • Rck antibody
      • RP62 antibody
      • Serine/threonine protein kinase MAK antibody
      • Serine/threonine-protein kinase MAK antibody
      • testicular secretory protein Li 28 antibody
      • wu:fj04c02 antibody
      • zgc:56603 antibody
      see all

    Anti-MAK antibody images



    • Predicted band size : 71 kDa
      MAK antibody (ab55453) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    References for Anti-MAK antibody (ab55453)

    ab55453 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab55453.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"