Overview

  • Product name
  • Description
    Rabbit polyclonal to MAL2
  • Tested applications
    Suitable for: ELISA, ICC, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the N-terminal domain of human MAL2

Properties

Applications

Our Abpromise guarantee covers the use of ab75347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
ICC 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 19 kDa.

Target

  • Function
    Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
  • Tissue specificity
    Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
  • Sequence similarities
    Belongs to the MAL family.
    Contains 1 MARVEL domain.
  • Cellular localization
    Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region.
  • Information by UniProt
  • Database links
  • Alternative names
    • MAL 2 antibody
    • MAL proteolipid protein 2 antibody
    • Mal, T cell differentiation protein 2 antibody
    • mal2 antibody
    • MAL2_HUMAN antibody
    • Protein MAL2 antibody
    see all

References

This product has been referenced in:
  • Li J  et al. The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PLoS One 12:e0178515 (2017). IHC-P ; Human . Read more (PubMed: 28562687) »
  • Katz E  et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 6:e17083 (2011). WB . Read more (PubMed: 21347235) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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