Malondialdehyde small molecule (ab126288)

Overview

  • Product name
    Malondialdehyde small molecule

Description

  • Nature
    Recombinant

Specifications

Our Abpromise guarantee covers the use of ab126288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Immunocytochemistry

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

  • Form
    Lyophilised
  • Additional notes
    This peptide was used as an immunogen for ab6463 - Malondialdehyde antibody.
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Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

  • Reconstitution
    For reconstitution, use pure water with 0.1% merthiolate. This solution is stable at +4°C for 1 month in darkness.

General Info

  • Alternative names
    • 1133 Tetramethoxypropane
    • MDA
  • Relevance
    Malondialdehyde (MDA) is a natural product formed in all mammalian cells as a product of lipid peroxidation. MDA is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine. The major adduct to DNA is a pyrimidopurinone called M1G which appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors. MDA modified proteins may show altered physico chemical behavior and antigenicity. MDA is toxic and has been implicated in aging mutagenesis, carcinogenesis, diabetic nephropathy and radiation damage. Increased expression of MDA has been reported in the brains of Alzheimer's patients. Antibodies to MDA will help to visualize the MDA adducts.

References

ab126288 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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The product is now available for sale and in our catalog as ab126288 - Malondialdehyde protein (BSA Conjugate)

http://www.abcam.com/index.html?datasheet=126288

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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