Recombinant
RabMAb

Anti-MALT1 antibody [EPR604] (ab109724)

Overview

  • Product name
    Anti-MALT1 antibody [EPR604]
    See all MALT1 primary antibodies
  • Description
    Rabbit monoclonal [EPR604] to MALT1
  • Tested applications
    Suitable for: WB, ICCmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human MALT1

  • Positive control
    • Jurkat,K562,bone marrow, and PBMC lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab109724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 92 kDa.
ICC 1/250 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function
      Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
    • Tissue specificity
      Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
    • Involvement in disease
      Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
    • Sequence similarities
      Belongs to the peptidase C14B family.
      Contains 1 death domain.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • Cellular localization
      Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
    • Information by UniProt
    • Database links
    • Alternative names
      • Caspase like protein antibody
      • DKFZp434L132 antibody
      • IMD12 antibody
      • MALT 1 antibody
      • MALT associated translocation antibody
      • MALT lymphoma associated translocation antibody
      • MALT lymphoma-associated translocation antibody
      • Malt1 antibody
      • MALT1 paracaspase antibody
      • MALT1_HUMAN antibody
      • MLT 1 antibody
      • MLT antibody
      • MLT1 antibody
      • Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody
      • Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody
      • Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody
      • Paracaspase antibody
      • Paracaspase-1 antibody
      • PCASP1 antibody
      see all

    Images

    • All lanes : Anti-MALT1 antibody [EPR604] (ab109724) at 1/1000 dilution

      Lane 1 : Jurkat lysate
      Lane 2 : K562 lysate
      Lane 3 : Bone marrow lysate
      Lane 4 : PBMC lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 92 kDa

    References

    ab109724 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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