Overview

  • Product nameAnti-MALT1 antibody [EPR604]
    See all MALT1 primary antibodies
  • Description
    Rabbit monoclonal [EPR604] to MALT1
  • Tested applicationsSuitable for: WB, ICCmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human MALT1

  • Positive control
    • Jurkat,K562,bone marrow, and PBMC lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab109724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 92 kDa.
ICC 1/250 - 1/500.
  • Application notesIs unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • FunctionEnhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
    • Tissue specificityHighly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
    • Involvement in diseaseNote=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
    • Sequence similaritiesBelongs to the peptidase C14B family.
      Contains 1 death domain.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • Cellular localizationCytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
    • Information by UniProt
    • Database links
    • Alternative names
      • Caspase like protein antibody
      • DKFZp434L132 antibody
      • MALT 1 antibody
      • MALT associated translocation antibody
      • MALT lymphoma associated translocation antibody
      • MALT lymphoma-associated translocation antibody
      • Malt1 antibody
      • MALT1_HUMAN antibody
      • MLT 1 antibody
      • MLT antibody
      • MLT1 antibody
      • Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody
      • Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody
      • Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody
      • Paracaspase antibody
      see all

    Anti-MALT1 antibody [EPR604] images

    • All lanes : Anti-MALT1 antibody [EPR604] (ab109724) at 1/1000 dilution

      Lane 1 : Jurkat lysate
      Lane 2 : K562 lysate
      Lane 3 : Bone marrow lysate
      Lane 4 : PBMC lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 92 kDa

    References for Anti-MALT1 antibody [EPR604] (ab109724)

    ab109724 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab109724.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"