Overview

  • Product name
    Anti-MALT1 antibody [MT1/410]
    See all MALT1 primary antibodies
  • Description
    Mouse monoclonal [MT1/410] to MALT1
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MALT1.
    Database link: Q9UDY8

  • Positive control
    • Human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab178581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/400. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
  • Tissue specificity
    Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
  • Involvement in disease
    Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
  • Sequence similarities
    Belongs to the peptidase C14B family.
    Contains 1 death domain.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization
    Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
  • Information by UniProt
  • Database links
  • Alternative names
    • Caspase like protein antibody
    • DKFZp434L132 antibody
    • IMD12 antibody
    • MALT 1 antibody
    • MALT associated translocation antibody
    • MALT lymphoma associated translocation antibody
    • MALT lymphoma-associated translocation antibody
    • Malt1 antibody
    • MALT1 paracaspase antibody
    • MALT1_HUMAN antibody
    • MLT 1 antibody
    • MLT antibody
    • MLT1 antibody
    • Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody
    • Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody
    • Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody
    • Paracaspase antibody
    • Paracaspase-1 antibody
    • PCASP1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MALT1 with ab178581 at 1/200 dilution followed by peroxidase-conjugate and DAB chromogen.

References

ab178581 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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