Overview

  • Product nameAnti-MAML1 antibody
    See all MAML1 primary antibodies
  • Description
    Rabbit polyclonal to MAML1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide corresponding to a region between residues 75 and 125 of Human MAML1 (NP_055572.1).

  • Positive control
    • Breast or ovarian carcinoma tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Antigen retrieval with tris-EDTA pH9.0 buffer recommended.
    Nore: likely to work also with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
    • Tissue specificityWidely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
    • Sequence similaritiesBelongs to the mastermind family.
    • DomainThe C-terminal region is required for transcriptional activation.
    • Cellular localizationNucleus speckle. Nuclear, in a punctate manner.
    • Information by UniProt
    • Database links
    • Alternative names
      • Mam-1 antibody
      • Mam1 antibody
      • MAML 1 antibody
      • Maml1 antibody
      • MAML1_HUMAN antibody
      • Mastermind like 1 antibody
      • Mastermind-like protein 1 antibody
      see all

    Anti-MAML1 antibody images

    • Immunohistochemical detection of Human MAML1 in formalin-fixed parafin-embedded Human ovarian carcinoma tissue using ab90654 at a dilution of 1/250 (DAB staining).

    References for Anti-MAML1 antibody (ab90654)

    ab90654 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"