Overview

  • Product nameAnti-MAML2 antibody
    See all MAML2 primary antibodies
  • Description
    Mouse monoclonal to MAML2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: RPPPDYKDQR RNVGNMQPTA QYSGGSSTIS LNSNQALANP VSTHTILTPN SSLLSTSHGT RMPSLSTAVQ NMGMYGNLPC NQPNTYSVTS GMNQLTQQR, corresponding to amino acids 796-895 of Human MAML2

Properties

Applications

Our Abpromise guarantee covers the use of ab57824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
    • Tissue specificityWidely expressed with high levels detected in placenta, salivary gland and skeletal muscle.
    • Involvement in diseaseNote=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
    • Sequence similaritiesBelongs to the mastermind family.
    • DomainThe C-terminal domain is required for transcriptional activation.
    • Cellular localizationNucleus speckle. Nuclear, in a punctate manner.
    • Information by UniProt
    • Database links
    • Alternative names
      • KIAA1819 antibody
      • Mam 2 antibody
      • Mam-2 antibody
      • MAML2 antibody
      • MAML2_HUMAN antibody
      • Mastermind-like protein 2 antibody
      see all

    Anti-MAML2 antibody images



    • Predicted band size : 125 kDa
      MAML2 antibody (ab57824) at 1ug/lane + MCF-7 cell lysate at 25ug/lane.

    References for Anti-MAML2 antibody (ab57824)

    ab57824 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"