Overview

  • Product name
  • Description
    Rabbit polyclonal to MAML2
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region between residue 1100 and the C-terminus (residue 1153) of Human MAML2 (AAK93831.1).

  • Positive control
    • Human Breast Carcinoma, Ovarian Carcinoma and Stomach Adenocarcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab90592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.

ICC/IF 1/50. PubMed: 25229469

Target

  • Function
    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
  • Tissue specificity
    Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.
  • Involvement in disease
    Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
  • Sequence similarities
    Belongs to the mastermind family.
  • Domain
    The C-terminal domain is required for transcriptional activation.
  • Cellular localization
    Nucleus speckle. Nuclear, in a punctate manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA1819 antibody
    • Mam 2 antibody
    • Mam-2 antibody
    • MAML2 antibody
    • MAML2_HUMAN antibody
    • Mastermind-like protein 2 antibody
    see all

Images

  • ab90592, at 1/250 dilution, staining MAML2 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry, using DAB detection.

References

This product has been referenced in:
  • Lim ML  et al. Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. PLoS One 9:e107712 (2014). ICC/IF ; Human . Read more (PubMed: 25229469) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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