The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use at an assay dependent concentration. Predicted molecular weight: 26 kDa.
FunctionCalcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Tissue specificityPlasma protein produced mainly in the liver.
Involvement in diseaseNote=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.
Mannose binding lectin protein C2 soluble opsonic defect antibody
Mannose binding protein antibody
Mannose binding protein C antibody
Mannose binding protein C precursor antibody
Mannose binding protein, serum antibody
Mannose-binding lectin antibody
Mannose-binding protein C antibody
MBL 2 antibody
MBP 1 antibody
MBP C antibody
Opsonic defect antibody
protein C antibody
Soluble mannose binding lectin antibody
References for Anti-Mannan Binding Lectin antibody [11C9] (ab26277)
This product has been referenced in:
Harboe M et al. Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions. Clin Exp Immunol144:512-20 (2006).
Read more (PubMed: 16734621) »
Larsen F et al. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J Biol Chem279:21302-11 (2004).
Read more (PubMed: 14764589) »