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Rabbit polyclonal to Mannose Phosphate Isomerase
Predicted to work with:
Mouse, Rat, Cow
Recombinant fragment, corresponding to amino acids 150-409 of Human Mannose Phosphate Isomerase (NP_002426)
293T, A431, H1299, HeLaS3, HepG2, MOLT4 and Raji lysates
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
1/100 - 1/250.
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Involvement in disease
Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy.
Belongs to the mannose-6-phosphate isomerase type 1 family.
Information by UniProt
Western blot - Mannose Phosphate Isomerase antibody (ab95972)
All lanes : Anti-Mannose Phosphate Isomerase antibody (ab95972) at 1/1000 dilution Lane 1 : 293T whole cell lysate Lane 2 : A431 whole cell lysate Lane 3 : H1299 whole cell lysate Lane 4 : HeLa S3 whole cell lysate Lane 5 : HepG2 whole cell lysate Lane 6 : MOLT4 whole cell lysate Lane 7 : Raji whole cell lysate Lysates/proteins at 30 µg per lane. Predicted band size : 46 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mannose Phosphate Isomerase antibody (ab95972)
Immunohistochemical analysis of paraffin-embedded human gastric CAN87 using ab95972 at 1/100 dilution.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"