Anti-Mannose Phosphate Isomerase antibody (ab96304)

Overview

  • Product name
    Anti-Mannose Phosphate Isomerase antibody
    See all Mannose Phosphate Isomerase primary antibodies
  • Description
    Rabbit polyclonal to Mannose Phosphate Isomerase
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a sequence within amino acids 1-164 of Human Mannose Phosphate Isomerase.

  • Positive control
    • NT2D1, IMR32, Jurkat or HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab96304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • Tissue specificity
    Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
  • Pathway
    Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
  • Involvement in disease
    Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy.
  • Sequence similarities
    Belongs to the mannose-6-phosphate isomerase type 1 family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • PMI1 antibody
    • CDG1B antibody
    • FLJ39201 antibody
    • Mannose 6 phosphate isomerase antibody
    • Mannose-6-phosphate isomerase antibody
    • MANNOSEPHOSPHATE ISOMERASE antibody
    • MGC94106 antibody
    • MPI antibody
    • MPI_HUMAN antibody
    • Phosphohexomutase antibody
    • phosphomannose isomerase 1 antibody
    • Phosphomannose isomerase antibody
    • PMI antibody
    see all

Images

  • Anti-Mannose Phosphate Isomerase antibody (ab96304) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

    Predicted band size : 40 kDa

References

ab96304 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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