Overview

  • Product name
    Mant-GTPγS (aqueous solution)
  • Description
    Potent, competitve adenylyl cyclase inhibitor. Fluorescent GTP derivative. eIF5B substrate.
  • Biological description
    Potent, competitive adenylyl cyclase inhibitor. Fluorescent GTP-γ-S (ab146662) derivative. eIF5B substrate. Noncompetitively inhibits GTP-γ-S-stimulated adenylyl cyclase in Galpha(s)-expressing Sf9 insect cell membranes.
  • Purity
    > 90%

Properties

  • Excitation
    355nm
  • Emission
    448nm
  • Molecular weight
    672.39
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H23N6O14P3S
  • CAS Number
    136749-24-1
  • Storage instructions
    Store at -20°C (desiccating conditions).
  • Solubility overview
    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Rottlaender D  et al. Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate. J Pharmacol Exp Ther 321:608-15 (2007). Read more (PubMed: 17284671) »
  • Pisareva VP  et al. Kinetic analysis of the interaction of guanine nucleotides with eukaryotic translation initiation factor eIF5B. Biochemistry 46:2622-9 (2007). Read more (PubMed: 17297921) »
  • Gille A & Seifert R MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors. Life Sci 74:271-9 (2003). Read more (PubMed: 14607255) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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