Overview

  • Product name
  • Description
    Rabbit polyclonal to MAP1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 15 internal sequence amino acids from Human MAP1.

  • Positive control
    • Human brain (cortex) tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -80°C.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115511 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
  • Tissue specificity
    Ubiquitously expressed with higher levels in heart and brain.
  • Sequence similarities
    Belongs to the PNMA family.
  • Domain
    The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.
  • Information by UniProt
  • Database links
  • Alternative names
    • MAP 1 antibody
    • MAP-1 antibody
    • MAP1 antibody
    • MOAP1 antibody
    • MOAP1_HUMAN antibody
    • Modulator of apoptosis 1 antibody
    • Modulator of Apoptosis antibody
    • Paraneoplastic antigen like 4 antibody
    • Paraneoplastic antigen Ma4 antibody
    • paraneoplastic Ma antigen family member 4 antibody
    • PNMA4 antibody
    see all

Images

  • ab115511 at 2.5ug/ml staining MAP1 in Human brain (cortex) tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115511 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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