Overview

  • Product nameAnti-MAP2 antibody [MT-07]
    See all MAP2 primary antibodies
  • Description
    Mouse monoclonal [MT-07] to MAP2
  • SpecificityRecognizes an epitope (aa 1375-1395) located in the central domain of MAP2. This epitope is present in MAP2b (200 kDa) and not present in MAP2c (50 kDa) nor isoform 4 (59 kDa).
  • Tested applicationsSuitable for: WB, IP, IHC-P, IHC-Fr, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Pig
  • Immunogen

    Protein fraction of Microtubule protein (bovine brain) enriched for kinesin.

  • Positive control
    • Human Brain, Cortex tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab118853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 199 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml.
IHC-Fr Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.

Target

  • FunctionThe exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
  • Sequence similaritiesContains 3 Tau/MAP repeats.
  • Post-translational
    modifications
    Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.
  • Cellular localizationCytoplasm, cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686I2148 antibody
    • MAP 2 antibody
    • MAP dendrite specific antibody
    • MAP-2 antibody
    • MAP2 antibody
    • MAP2A antibody
    • MAP2B antibody
    • MAP2C antibody
    • Microtubule associated protein 2 antibody
    • Microtubule-associated protein 2 antibody
    • MTAP2_HUMAN antibody
    see all

Anti-MAP2 antibody [MT-07] images

  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained withab118853 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-MAP2 antibody [MT-07] (ab118853)

ab118853 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"