Recombinant
RabMAb

Anti-MAP3K8 antibody [EP1103Y] (ab52613)

Overview

  • Product name
    Anti-MAP3K8 antibody [EP1103Y]
    See all MAP3K8 primary antibodies
  • Description
    Rabbit monoclonal [EP1103Y] to MAP3K8
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human)

  • Positive control
    • Jurkat cell lysate
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab52613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 53 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function
      Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
    • Tissue specificity
      Expressed in several normal tissues and human tumor-derived cell lines.
    • Sequence similarities
      Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
      Contains 1 protein kinase domain.
    • Developmental stage
      Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
    • Post-translational
      modifications
      Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • AURA2 antibody
      • c COT antibody
      • Cancer Osaka thyroid oncogene antibody
      • CCOT antibody
      • COT antibody
      • COT proto oncogene serine/threonine protein kinase antibody
      • EST antibody
      • ESTF antibody
      • Ewing sarcoma transformant antibody
      • FLJ10486 antibody
      • M3K8_HUMAN antibody
      • MAP3K 8 antibody
      • MAP3K8 antibody
      • MEKK8 antibody
      • Mitogen activated protein kinase kinase kinase 8 antibody
      • Mitogen-activated protein kinase kinase kinase 8 antibody
      • Proto oncogene cCot antibody
      • Proto-oncogene c-Cot antibody
      • Serine/threonine protein kinase cot antibody
      • Serine/threonine-protein kinase cot antibody
      • TPL 2 antibody
      • TPL-2 antibody
      • TPL2 antibody
      • Tumor progression locus 2 antibody
      see all

    Images

    • Anti-MAP3K8 antibody [EP1103Y] (ab52613) at 1/500 dilution + Jurkat cell lysate at 10 µg

      Secondary
      Goat anti-rabbit HRP antibody at 1/2000 dilution

      Predicted band size: 53 kDa
      Observed band size: 53 kDa

    References

    ab52613 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab52613.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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