Overview

  • Product nameAnti-MAP3K8 antibody [EP1103Y]
    See all MAP3K8 primary antibodies
  • Description
    Rabbit monoclonal [EP1103Y] to MAP3K8
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human)

  • Positive control
    • Jurkat cell lysate
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab52613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 53 kDa.
  • Application notesIs unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • FunctionRequired for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
    • Tissue specificityExpressed in several normal tissues and human tumor-derived cell lines.
    • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
      Contains 1 protein kinase domain.
    • Developmental stageIsoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
    • Post-translational
      modifications
      Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • c COT antibody
      • Cancer Osaka thyroid oncogene antibody
      • CCOT antibody
      • COT antibody
      • COT proto oncogene serine/threonine protein kinase antibody
      • EST antibody
      • ESTF antibody
      • Ewing sarcoma transformant antibody
      • FLJ10486 antibody
      • M3K8_HUMAN antibody
      • MAP3K 8 antibody
      • MAP3K8 antibody
      • MEKK8 antibody
      • Mitogen activated protein kinase kinase kinase 8 antibody
      • Mitogen-activated protein kinase kinase kinase 8 antibody
      • Proto oncogene cCot antibody
      • Proto-oncogene c-Cot antibody
      • Serine/threonine protein kinase cot antibody
      • Serine/threonine-protein kinase cot antibody
      • TPL 2 antibody
      • TPL-2 antibody
      • TPL2 antibody
      • Tumor progression locus 2 antibody
      see all

    Anti-MAP3K8 antibody [EP1103Y] images

    • Anti-MAP3K8 antibody [EP1103Y] (ab52613) at 1/500 dilution + Jurkat cell lysate at 10 µg

      Secondary
      Goat anti-rabbit HRP antibody at 1/2000 dilution

      Predicted band size : 53 kDa
      Observed band size : 53 kDa

    References for Anti-MAP3K8 antibody [EP1103Y] (ab52613)

    ab52613 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"