The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100.
1/100 - 1/500. Detects a band of approximately 100 kDa (predicted molecular weight: 118 kDa).
FunctionActivates the JUN N-terminal pathway.
Tissue specificityExpressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain.
Post-translational modificationsAutophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.
ab71628 at 1/50 dilution, staining MAP3K9 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.
References for Anti-MAP3K9 antibody - C-terminal (ab71628)
This product has been referenced in:
Tivnan A et al. MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma. BMC Cancer11:33 (2011).
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