Anti-MAPK11 antibody - Carboxyterminal end (ab37937)

Overview

  • Product name
    Anti-MAPK11 antibody - Carboxyterminal end
    See all MAPK11 primary antibodies
  • Description
    Rabbit polyclonal to MAPK11 - Carboxyterminal end
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide, selected from C terminal amino acids 356-372 of human MAPK11.

  • Positive control
    • Human placenta lysate, and human breast carcinoma and human hepatocarcinoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    Eluted out with both high and low pH buffers and neutralized immediately after elution, followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab37937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 42 kDa.
IHC-P 1/50 - 1/100.

Target

  • Function
    Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
  • Tissue specificity
    Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • Domain
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Post-translational
    modifications
    Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
  • Information by UniProt
  • Database links
  • Alternative names
    • Human p38Beta MAP kinase mRNA complete cds antibody
    • MAP kinase 11 antibody
    • MAP kinase p38 beta antibody
    • MAPK 11 antibody
    • Mapk11 antibody
    • Mitogen activated protein kinase 11 antibody
    • Mitogen activated protein kinase p38 2 antibody
    • Mitogen activated protein kinase p38 beta antibody
    • Mitogen-activated protein kinase 11 antibody
    • Mitogen-activated protein kinase p38 beta antibody
    • MK11_HUMAN antibody
    • p38 2 antibody
    • p38-2 antibody
    • p38B antibody
    • p38Beta antibody
    • P38BETA2 antibody
    • PRKM11 antibody
    • Protein kinase mitogen activated 11 antibody
    • SAPK2 antibody
    • SAPK2B antibody
    • Stress activated protein kinase 2 antibody
    • Stress activated protein kinase 2b antibody
    • Stress-activated protein kinase 2 antibody
    see all

Images

  • Anti-MAPK11 antibody - Carboxyterminal end (ab37937) at 1/100 dilution + Human placenta lysate

    Observed band size : 42 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labeling MAPK11 with ab37937 at a 1/50 dilution.

     

References

ab37937 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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